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Health Care, Health Disparities, Healthcare, Public Health, Science, Uncategorized

‘Silent Killer’: Undiagnosed Chagas Disease Emerging As New Threat To U.S. Public Health

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Chagas disease, a parasitic infection that can lead to severe heart disease and death, affects millions of people worldwide, mainly in Latin America. Now, new research shows the disease is on the rise in the southern United States, emerging as a new public health threat for Americans.

Researchers from Baylor College of Medicine in Houston, TX, presented the results of their work on Tuesday (11/4) at the 63rd Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH) in New Orleans, LA. They say a broad swath of the southern United States faces a tangible but mostly unrecognized risk of contracting Chagas disease.

Chagas disease (American trypanosomiasis) is caused by Trypanosoma cruzi, a protozoan parasite related to the African Trypanosoma that causes sleeping sickness (African trypanosomiasis). The infection is typically spread to people through the feces of blood-sucking triatomine bugs sometimes called “kissing bugs” because they feed on people’s faces during the night.

Once the parasite enters the bloodstream, it travels to the heart and settles there, and damages the heart muscle. Up to 30 percent of infected people have chronic heart disorders and up to 10 percent get sick with other health problems including digestive and neurological disorders.

The disease, which can also be spread through blood supply, affects 7 to 8 million people worldwide and can be cured — but only if it is caught early. Many infected people do not realize they have Chagas until symptoms become severe – and even then, they can be misdiagnosed as other conditions, such as cardiovascular disease.

Often considered a problem only in Mexico, Central America and South America, Chagas disease is being seen in Texas and recognized at higher levels than previously believed, the Baylor researchers reported. Most of those infected are believed to have contracted the disease within the U.S. border, according to the scientists whose findings will also be published in the American Journal of Tropical Medicine and Hygiene.

“We were astonished to not only find such a high rate of individuals testing positive for Chagas in their blood, but also high rates of heart disease that appear to be Chagas-related,” said Baylor epidemiologist Dr. Melissa Nolan Garcia, one of the researchers who presented findings from a series of studies. “We’ve been working with physicians around the state to increase awareness and diagnosis of this important emerging infectious disease.”

And while this research was conducted in Texas, kissing bugs are found across half of the United States, according to the U.S. Centers for Disease Control and Prevention (CDC). Bites from these insects may be infecting people who are never diagnosed, due to a lack of awareness of Chagas disease by healthcare personnel and the U.S. healthcare system, the researchers warn.

Undiagnosed Chagas Disease is a ‘Silent Killer’

Dr. Garcia’s team has been investigating Chagas disease for years, but only recently have they found evidence indicating that the infection may be vastly underreported in official figures. In one arm of the research, the Baylor scientists conducted an analysis of routine testing for Chagas among Texas blood donors between 2008 and 2012 to determine the prevalence in the population. Since 2007, all potential blood donors within the United States are screened for exposure to the Chagas disease parasite.

Their findings – published in the August 2014 issue of the journal Epidemiology and Infection – showed that one in every 6,500 blood donors tested positive for exposure to the parasite that causes Chagas disease. That figure is 50 times higher than the CDC’s estimated infection rate of one in 300,000 nationally, but according to Dr. Garcia, it is consistent with other studies in the southern United States indicating a substantial national disease burden.

Researchers say the prevalence of the parasitic infection Chagas disease may be up to 50 times higher than previously thought.

Researchers say the prevalence of the parasitic infection Chagas disease may be up to 50 times higher than previously thought.

“We think of Chagas disease as a silent killer,” Garcia said. “People don’t normally feel sick, so they don’t seek medical care, but it ultimately ends up causing heart disease in about 30 percent of those who are infected.”

Symptoms of the infection can range from non-existent to severe with fever, fatigue, body aches, and serious cardiac and intestinal complications. Positive blood donors, who would likely develop chronic Chagas disease over time, could cost about $3.8 million for health care and lost wages for those individuals, the researchers calculated. And according to a 2013 study published in the The Lancet Infectious Diseases, societal and healthcare costs for each infected person in the United States averages $91,531, costing the American economy more than $900 million each year.

“We’re the first to actively follow up with positive blood donors to assess their cardiac outcomes and to determine where southeastern Texas donors may have been exposed to Chagas,” Dr. Garcia said. “We are concerned that individuals who test positive are not seeking medical care or being evaluated for treatment. And even if they do seek medical care, we heard from some patients that their primary care doctors assumed the positive test represented a ‘false positive’ due to low physician awareness of local transmission risk.”

Dr. Garcia also shared the findings from separate pilot studies conducted by the Baylor team, which followed 17 Houston-area residents who were infected. They found that 41 percent of them had signs of heart disease caused by the infection, including swollen, weakened heart muscle and irregular heart rhythms caused by the parasite burrowing into heart tissue. Most of these individuals lived in rural areas or spent a significant amount of time outside. One of the individuals was an avid hunter and outdoorsman. At least six of them had insignificant travel outside the United States and they didn’t have mothers from foreign countries, indicating they had likely become infected locally in Texas.

As blood donor screening is currently the only active screening program in the United States, they provide an insight into the characteristics of who might be at risk for disease. “People who give blood are usually generally healthy adults. The people that we worry about in terms of burden of disease here are from rural settings and people who live in severe poverty. So the burden of disease may be even higher than what we see in this study,” said Dr. Kristy Murray, DVM, PhD, a co-author on the study and associate professor of tropical medicine at Baylor.

New Analysis of CDC Data and National Blood Bank Data Uncovers Large Treatment Gap

In a related study also presented at the ASTMH Annual Meeting, researchers found that people who test positive for Chagas disease mostly go untreated. Dr. Jennifer Manne-Goehler, MD, a clinical fellow at Harvard Medical School and Beth Israel Deaconess Medical Center, collected data from the CDC and the American Association of Blood Banks and compared the almost 2,000 people who tested positive through the blood banking system to the mere 422 doses of medications administered by the CDC from 2007 to 2013.

“This highlights an enormous treatment gap,” said Dr. Manne-Goehler. “In some of the areas of the country we know there are a lot of positive blood donors, yet people still don’t get care. We don’t know what happens to them because there is no follow up.”

High rates of untreated Chagas disease indicate that a large number of people may be at risk for serious complications including heart problems and death.

High rates of untreated Chagas disease indicate that a large number of people may be at risk for serious complications including heart problems and death.

In the United States, most physicians are unfamiliar with the disease, and some who have heard of it mistakenly dismiss Chagas disease as a not-so-serious health concern, even in parts of the country where many people may be living with Chagas symptoms, she said at an ASTMH presentation on access to treatment. Further complicating the situation, in the United States the currently available medicines used to treat Chagas disease have not been approved by the U.S. Food and Drug Administration. Physicians seeking treatment for their patients are referred to the CDC, which makes two drugs — nifurtimox and benznidazole — available, both of which carry the risk of side effects including nausea, weight loss and possible nerve damage.

In addition to data collection, Dr. Manne-Goehler conducted interviews with physicians, state health directors, and other healthcare workers treating patients diagnosed with Chagas disease in states with higher numbers of cases: Texas, California, Florida, Virginia, New York and Massachusetts. The findings revealed a disjointed, ad hoc approach to both diagnosing and treating the disease. Most of the doctors interviewed had never treated a patient whose infection had been identified through the blood donor system.

Dr. Manne-Goehler and her colleagues Dr. Michael Reich, PhD, of the Harvard School of Public Health and Dr. Veronika Wirtz PhD, of the Boston University Center for Global Health and Development, are calling for the creation of an independent expert panel to define clinical screening guidelines to help improve identification of patients with Chagas disease in the United States. In addition, they argue for creation of a physician-referral network so that physicians who are unfamiliar with the disease can send patients to providers who regularly diagnose and treat cases of Chagas disease.

Several ASTMH presenters also argued for a more comprehensive system of surveillance beyond testing of blood donors.

“So little surveillance has been done that we don’t know the true disease burden here in the United States,” added Dr. Murray. “The next step is to study populations considered high risk. There is still a lot to be learned in terms of who is contracting the disease within the United States.”

 

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